Genzyme begins expansion of Boston manufacturing plant

Genzyme Corporation on September 18 broke ground on a significant expansion of its flagship manufacturing facility at Allston Landing in Boston. The $150 million project is focused on adding space for manufacturing support functions, and will allow for the creation of 90 jobs.

The expansion was marked by a ceremony featuring Massachusetts Governor Deval L. Patrick, Boston Mayor Thomas M. Menino, and 5-year-old Pompe patient Megan Assink along with her parents, Greg and Deb, and her sister, Hope. The event was attended by more than 500 people, including local political and business leaders, members of the Allston community, patient organizations, foreign government officials, and Genzyme employees.

Commercial production of a single product began at Allston Landing in 1996; Genzyme has since introduced four additional products to the facility. This substantial growth in manufacturing capacity has led to the need for greater space for manufacturing support operations, offices and mechanical equipment.

"The expansion of Allston Landing will help sustain the continued growth of Genzyme's products," said Henri A. Termeer, chairman and chief executive officer of Genzyme. "It will enable us to continue to fulfill our long-term commitment to deliver these life-saving treatments to patients around the world."

Allston Landing was Genzyme's first major manufacturing facility and is now one of 17 worldwide. Thousands of patients rely on the medicines produced at Allston, which is one of the world's largest cell-culture manufacturing facilities. The expansion project includes 86,000 square feet of new office and manufacturing-support space. Genzyme is also building a 26,000-square-foot underground co-generation facility, which will generate steam to run the plant's process operations and will also produce electricity.

Genzyme began construction of Allston Landing in the early 1990s, and the facility was initially intended to produce one product – Cerezyme (imiglucerase for injection) for Type 1 Gaucher disease. While the physical size and layout of the facility have remained largely unchanged, Genzyme is now producing five products at the facility. Three are manufactured there: Cerezyme; Fabrazyme (agalsidase beta) for Fabry disease; and Myozyme (alglucosidase alfa) for Pompe disease. Genzyme also performs the filling and packaging for two products manufactured at other sites: Aldurazyme (laronidase) for MPS I disease and Thyrogen (thyrotropin alfa for injection), used in the screening of patients who have had thyroid cancer. Genzyme last expanded the site in 2004.

The Allston Landing facility is a highly visible landmark located between Storrow Drive and the Massachusetts Turnpike. The design and brick facade of the existing building establish a strong visual link to nearby universities. The expanded site has been designed to reflect a significantly more modern and transparent image, in keeping with Genzyme's continuing desire to embrace these qualities in its corporate culture. The design also will serve to symbolically open up the facility to the surrounding community.

The Allston expansion will incorporate environmentally responsible building practices similar to those used in Genzyme Center – the company's Cambridge headquarters – and its new Science Center in Framingham. Genzyme intends to seek certification for the expansion under the U.S. Green Building Council's LEED (Leadership in Energy and Environmental Design) Green Building Rating System.